Balance between protective and harmful subsets of microglia in an aging brain. Dr. Pinar Ayata (Advanced Science Research Center, CUNY).

Microglia, the resident macrophages of the brain, perform homeostatic functions that support the health and function of neurons and are implicated in neurological disorders. The first part of the talk will focus on the brain region-specific diversity of microglia and an epigenetic mechanism underpinning their diversity, which is necessary for normal brain function. Second part of the talk will focus on the transcriptional and signaling mechanisms governing the diversity of microglia in Alzheimer's Disease, where some subsets prevent disease progression while others aggravate it. Together these results attribute a critical role for the population balance of microglia in neurodegeneration

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