Wed. 5/22 Biology Seminar, 1:15 pm - Meghan Lockhard

Meghan Lockard (Rockefeller University): “La Dolce Verma: Oxytocin, Dopamine, and their Role as Comodulators in Nematode Nooky”, 1:15 -2:15 pm, Rm. 926HN

Oxytocin has been known to the biomedical community for 150 years as being a regulator of complex reproductive behavior and physiological processes in mammals and other vertebrates, but evolutionary the neuropeptide emerged in metazoans about 700 million years ago, around the same time as bilateral symmetry. In every instance where it has been studied, from nematodes to humans, oxytocin homologs have been shown to play a role in mate search, mating, and/or provisioning of offspring. What is the basis for this genetic and functional conservation?  To address this, I looked at the functional role of oxytocin in modulating the mating circuit of the nematode C. elegans. Like its mammalian homolog, nematocin comodulates mating behavior with the nonclassical neurotrasmitter dopamine. Through genetics, neuronal imaging, and circuit manipulation, I show how the timing and levels of nematocin release are critical for the male to mate with coherence and momentum. Dopamine couples this release with specific stimuli from mating via the antagonism between a D1-like and a D2-like receptor expressed in the same nematocin releasing neuron, DVA.  The circuit serves as a model for how a simple, highly conserved repertoire of neuromodulators could generate some of nature's richest and most complex behaviors.

5/13 Biology Seminar 12pm - Mitchell Goldfarb

Looking forward to our own Mitch Goldfarb (Hunter College) share his recent work at the Biology Seminar, 12pm, Rm. 926HN

“FHF Modulation of Sodium Channel Inactivation Gating in Cardiac and Nerve Conduction: Empirical and Computational Findings”.

2nd Annual ASRC Glia Symposium - Nov. 13, Today!

Glial response to environmental signals and glial cross-talk, 8:30 am - 7pm

Auditorium, Advanced Science Research Center

85 St. Nicholas Terr., NYC, 10031

FEATURED SPEAKERS  Vittorio Gallo, Ph.D., Children’s National Health System  Margot Mayer-Pröschel, Ph.D., University of Rochester Medical Center  Orna Issler, Ph.D., Icahn School of Medicine at Mount Sinai  Shane Liddelow, Ph.D., NYU Langone Medical Center  Akiko Nishiyama, M.D., Ph.D. , University of Connecticut at Storrs  Sam Horng, M.D., Ph.D., Icahn School of Medicine at Mount Sinai  Pablo Paez, Ph.D., University at Buffalo  Jia Liu , Ph.D., Advanced Science Research Center at GC/CUNY  Anna Jagielska, Ph.D., Massachusetts Institute of Technology  Ana Badimon, Icahn School of Medicine at Mount Sinai

FEATURED SPEAKERS

Vittorio Gallo, Ph.D., Children’s National Health System

Margot Mayer-Pröschel, Ph.D., University of Rochester Medical Center

Orna Issler, Ph.D., Icahn School of Medicine at Mount Sinai

Shane Liddelow, Ph.D., NYU Langone Medical Center

Akiko Nishiyama, M.D., Ph.D. , University of Connecticut at Storrs

Sam Horng, M.D., Ph.D., Icahn School of Medicine at Mount Sinai

Pablo Paez, Ph.D., University at Buffalo

Jia Liu , Ph.D., Advanced Science Research Center at GC/CUNY

Anna Jagielska, Ph.D., Massachusetts Institute of Technology

Ana Badimon, Icahn School of Medicine at Mount Sinai