Paper We're Discussing This Week:

Mueller-Buehl, C., Pakusch, J., Bader, V. et al. (2025) Combined loss of brevican, neurocan, tenascin-C and tenascin-R leads to impaired fear retrieval due to perineuronal net loss. Sci Rep 15, 5528. https://doi.org/10.1038/s41598-025-89580-2

Previously:

Zhang X., Flick K., Rizzo M., Pignatelli M., Tonegawa S. (2025) Dopamine induces fear extinction by activating the reward-responding amygdala neurons. Proc Natl Acad Sci U S A. 6;122(18):e2501331122. https://doi.org/10.1073/pnas.2501331122

Adkins JM, Halcomb CJ, Rogers D, Jasnow AM. Stress and sex-dependent effects on conditioned inhibition of fear. Learn Mem. 2022 Sep 2;29(9):246-255. doi: 10.1101/lm.053508.121.

Xin, W., Kaneko, M., Roth, R.H. et al. (2024) Oligodendrocytes and myelin limit neuronal plasticity in visual cortex. Nature 633, 856–863. https://doi.org/10.1038/s41586-024-07853-8

Krueger JN, Patel NN, Shim K, Ng K, Sangha S. (2024) Conditioned inhibition of fear and reward in male and female rats. Neurobiol Learn Mem. 208:107881. doi: 10.1016/j.nlm.2023.107881.

Dallérac, G., Graupner, M., Knippenberg, J. et al. (2017( Updating temporal expectancy of an aversive event engages striatal plasticity under amygdala control. Nat Commun 8, 13920. https://doi.org/10.1038/ncomms13920

Kim R., Ananth M.R., Desai N.S., Role L.W., Talmage D.A. (2024) Distinct subpopulations of ventral pallidal cholinergic projection neurons encode valence of olfactory stimuli. Cell Reports 43: 114009 https://www.cell.com/cell-reports/pdf/S2211-1247(24)00337-1.pdf#page18

Gu X., Johansen J.P. (2024) Prefrontal encoding of an internal model for emotional inference. BioRxiv: https://doi.org/10.1101/2024.04.22.590529

Li HQ, Jiang W, Ling L, Pratelli M, Chen C, Gupta V, Godavarthi SK, Spitzer NC. (2024) Generalized fear after acute stress is caused by change in neuronal cotransmitter identity. Science. 383:1252-1259. doi: 10.1126/science.adj5996.

Zhang X, Liu Y, Hong X, Li X, Meshul CK, Moore C, Yang Y, Han Y, Li WG, Qi X, Lou H, Duan S, Xu TL, Tong X. (2021) NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety. Nat Commun. 12(1):5740. doi: 10.1038/s41467-021-25956-y.

Zhu F, Elnozahy S, Lawlor J, Kuchibhotla KV. The cholinergic basal forebrain provides a parallel channel for state-dependent sensory signaling to auditory cortex. (2023) Nat Neurosci. 26:810-819. doi: 10.1038/s41593-023-01289-5.

Yamada J, Maeda S, Tojo M, Hayashida M, Iinuma KM, Jinno S. (2023) Altered regulation of oligodendrocytes associated with parvalbumin neurons in the ventral hippocampus underlies fear generalization in male mice. Neuropsychopharm. 48:1668-1679. doi: 10.1038/s41386-023-01611-6.

Sun W, Liu Z, Jiang X, Chen MB, Dong H, Liu J, Südhof TC, Quake SR. (2024) Spatial transcriptomics reveal neuron-astrocyte synergy in long-term memory. Nature. Mar;627(8003):374-381. https://www.nature.com/articles/s41586-023-07011-6

Walker EY, Pohl S, Denison RN, Barack DL, Lee J, Block N, Ma WJ, Meyniel F. (2023) Studying the neural representations of uncertainty. Nature Neuroscience, 10.1038/s41593-023-01444-y

Asokan M.M., Watanabe Y., Kimchi E.Y., Polley D.B. (2023) Potentiation of cholinergic and corticofugal inputs to the lateral amygdala in threat learning. Cell Reports 42: 113167.

Yu H, Chen L, Lei H, Pi G, Xiong R, Jiang T, Wu D, Sun F, Gao Y, Li Y, Peng W, Huang B, Song G, Wang X, Lv J, Jin Z, Ke D, Yang Y, Wang JZ. (2022) Infralimbic medial prefrontal cortex signalling to calbindin 1 positive neurons in posterior basolateral amygdala suppresses anxiety- and depression-like behaviours. Nat Commun. 13:5462.

Cummings KA, Bayshtok S, Dong TN, Kenny PJ, Clem RL. (2022) Control of fear by discrete prefrontal GABAergic populations encoding valence-specific information. Neuron, doi: 10.1016/j.neuron.2022.07.004.

Yanpallewar S, Tomassoni-Ardori F, Palko ME, Hong Z, Kiris E, Becker J, Fulgenzi G, Tessarollo L. (2022) TrkA-cholinergic signaling modulates fear encoding and extinction learning in PTSD-like behavior. Transl Psychiatry 12(1):111.

Ben-Ami Bartal I, Rodgers DA, Bernardez Sarria MS, Decety J, Mason P. (2014) Pro-social behavior in rats is modulated by social experience. Elife 3:e01385

Huggins A.A, Weis C.N., Parisi E.A., Bennett K.P., Miskovic V., Larson C.L. (2021) Neural substrates of human fear generalization: A 7T-fMRI investigation. Neuroimage 239: 118308.

Fu X, Teboul E, Weiss GL, Antonoudiou P, Borkar CD, Fadok JP, Maguire J, Tasker JG. (2022) Gq neuromodulation of BLA parvalbumin interneurons induces burst firing and mediates fear-associated network and behavioral state transition in mice. Nat Comm 13: 1290.

LA Osso, KA Rankin, JR Chan (2021) Experience-dependent myelination following stress is mediated by the neuropeptide dynorphin Neuron 109: 3619-3632.e5

Rachel A. Walker, Rebecca L. Suthard, Taylor N. Perison, Nora M. Sheehan, Caitlin C. Dwyer, Jillian K. Lee, Eghosa K. Enabulele, Madelyn H. Ray and Michael A. McDannald (2022) Dorsal raphe 5-HT neurons utilize, but do not generate, negative aversive prediction errors eNeuro. 0132-21.2022

Joffe ME, Maksymetz J, Luschinger JR, Dogra S, Ferranti AS, Luessen DJ, Gallinger IM, Xiang Z, Branthwaite H, Melugin PR, Williford KM, Centanni SW, Shields BC, Lindsley CW, Calipari ES, Siciliano CA, Niswender CM, Tadross MR, Winder DG, Conn PJ. (2022) Acute restraint stress redirects prefrontal cortex circuit function through mGlu 5 receptor plasticity on somatostatin-expressing interneurons. Neuron S0896-6273: 01044-8.

Sánchez-Bellot C, AlSubaie R, Mishchanchuk K, Wee RWS, MacAskill AF. (2022) Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour. Nat Comm 13: 339

Whittle N, Fadok J, MacPherson KP, Nguyen R, Botta P, Wolff SBE, Müller C, Herry C, Tovote P, Holmes A, Singewald N, Lüthi A, Ciocchi S. (2021) Central amygdala micro-circuits mediate fear extinction. Nat Comm 12: 4156

Lazic SE. (2010) The problem of pseudoreplication in neuroscientific studies: is it affecting your analysis? BMC Neurosci 11:5.

Yu W, Pati D, Pina MM, Schmidt KT, Boyt KM, Hunker AC, Zweifel LS, McElligott ZA, Kash TL (2021) Periaqueductal gray/dorsal raphe dopamine neurons contribute to sex differences in pain-related behaviors. Neuron 109:1365-1380.

Benamer N, Vidal M, Balia M, Angulo MC. (2020) Myelination of parvalbumin interneurons shapes the function of cortical sensory inhibitory circuits. Nat Communications 11:5151.

Cai LX, Pizano K, Gundersen GW, Hayes CL, Fleming WT, Holt S, Cox JM, Witten IB. (2020) Distinct signals in medial and lateral VTA dopamine neurons modulate fear extinction at different times. eLife: 9:e54936. doi:10.7554/eLife.54936.

Shine JM, Müller EJ, Munn B, Cabral J, Moran RJ, Breakspear M. (2021)
Computational models link cellular mechanisms of neuromodulation to large-scale neural dynamics. Nat Neurosci. doi: 10.1038/s41593-021-00824-6.

Khalighinejad N, Bongioanni A, Verhagen L, Folloni D, Attali D, Aubry JF, Sallet J, Rushworth MFS. (2020) A Basal Forebrain-Cingulate Circuit in Macaques Decides It Is Time to Act. Neuron 105: 37-384.

Sohn JMB, de Souza STF, Raymundi AM, Bonato J, de Oliveira RMW, Prickaerts J, Stern CA. (2020) Persistence of the extinction of fear memory requires late-phase cAMP/PKA signaling in the infralimbic cortex. Neurobiol Learn Mem. 172:107244.

Kim CK, Sanchez MI, Hoerbelt P., Fenno LE, Malenka RC, Deisseroth K, Ting AY (2020) A Molecular Calcium Integrator Reveals a Striatal Cell Type Driving Aversion. Cell 183: 2003-2019.

Pan S., Mayoral S.R., Choi H.S., Chan J.R., Kheirbek M. (2020) Preservation of a remote fear memory requires new myelin formation. Nat. Neurosci 23: 487-499.

Qin C, Bian XL, Wu HY, Xian JY, Cai CY, Lin YH, Zhou Y, Kou XL, Chang L, Luo CX, Zhu DY. (2020) Dorsal Hippocampus to Infralimbic Cortex Circuit is Essential for the Recall of Extinction Memory. Cereb Cortex Nov 14;bhaa320.

Cho KKA, Davidson TJ, Bouvier G, Marshall JD, Schnitzer MJ, Sohal VS. (2020) Cross-hemispheric gamma synchrony between prefrontal parvalbumin interneurons supports behavioral adaptation during rule shift learning. Nat Neurosci. 23:892-902.

Companion discussion paper:

Buzsáki G, Schomburg EW. (2015) What does gamma coherence tell us about inter-regional neural communication? Nat Neurosci.18:484-9.

Lovett-Barron M, Chen R, Bradbury S, Andalman AS, Wagle M, Guo S, Deisseroth K. (2020) Multiple convergent hypothalamus-brainstem circuits drive defensive behavior. Nat Neurosci.

McMurray KMJ, Gray A, Horn P, Sah R. (2020) High Behavioral Sensitivity to Carbon Dioxide Associates with Enhanced Fear Memory and Altered Forebrain Neuronal Activation. Neuroscience 429: 92-105.

Day HLL, Suwansawang S, Halliday DM, Stevenson CW. (2020) Sex differences in auditory fear discrimination are associated with altered medial prefrontal cortex function. Sci Rep. 10:6300.

van Holstein M., MacLeod P.E., Floresco S. (2019) Basolateral amygdala - nucleus accumbens circuitry regulates optimal cue-guided risk/reward decision making. Prog Neuropsychopharm and Biol Psych. 98: 109830.

Dolensek N, Gehrlach DA, Klein AS, Gogolla N. (2020) Facial expressions of emotion states and their neuronal correlates in mice. Science 368 :89-94.

Dabney W., Kurth-Nelson Z., Uchida N., Starkweather C.K., Hassabis D., Munos R., Botvinick M. (2020) A Distributional Code for Value in Dopamine-Based Reinforcement Learning. Nature 577: 671-675.

Gao C, Leng Y, Ma J, Rooke V, Rodriguez-Gonzalez S, Ramakrishnan C, Deisseroth K, Penzo MA. (2020) Two genetically, anatomically and functionally distinct cell types segregate across anteroposterior axis of paraventricular thalamus. Nat Neurosci. 23:217-228.

Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, Gonçalves WA, Shwartz Y, Fast EM, Su Y, Zon LI, Regev A, Buenrostro JD, Cunha TM, Chiu IM, Fisher DE, Hsu YC. (2020) Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature 577:676-681.

Scheggia D, Managò F, Maltese F, Bruni S, Nigro M, Dautan D, Latuske P, Contarini G, Gomez-Gonzalo M, Requie LM, Ferretti V, Castellani G, Mauro D, Bonavia A, Carmignoto G, Yizhar O, Papaleo F. Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice (2020) Nature Neurosci 23:47-60.

Blume R.S., Padival M., Urban J.H., Rosenkranz A.J. (2019) Disruptive effects of repeated stress on basolateral amygdala neurons and fear behavior across the estrous cycle. Sci Rep 9:12292. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707149/

Forkosh O, Karamihalev S, Roeh S, Alon U, Anpilov S, Touma C, Nussbaumer M, Flachskamm C, Kaplick PM, Shemesh Y, Chen A.(2019) Identity domains capture individual differences from across the behavioral repertoire. Nature Neuroscience. Nov. 4.

Kasugai Y, Vogel E, Hörtnagl H, Schönherr S, Paradiso E, Hauschild M, Göbel G, Milenkovic I, Peterschmitt Y, Tasan R, Sperk G, Shigemoto R, Sieghart W, Singewald N, Lüthi A, Ferraguti F. (2019) Structural and Functional Remodeling of Amygdala GABAergic Synapses in Associative Fear Learning. Neuron 104:1-14.

Smith EH, Horga G, Yates MJ, Mikell CB, Banks GP, Pathak YJ, Schevon CA, McKhann II GM, Hayden BY, Botvinick MM, Sheth SA. (2019) Widespread temporal coding of cognitive control in the human prefrontal cortex. Nature Neuro, https://www.nature.com/articles/s41593-019-0494-0

Du. J., Price M.P., Taugher R.J., Gigsby D., Ash J.J., Stark A.C., Saad M.Z.H., Singh K., Mandal J., Wemmie J.A., Welsh M.J. (2017) Transient acidosis while retrieving a fear-related memory enhances its lability. eLife;6:e22564.

Hasan MT, Althammer F, Silva da Gouveia M, Goyon S, Eliava M, Lefevre A, Kerspern D, Schimmer J, Raftogianni A, Wahis J, Knobloch-Bollmann HS, Tang Y, Liu X, Jain A, Chavant V, Goumon Y, Weislogel JM, Hurlemann R, Herpertz SC, Pitzer C, Darbon P, Dogbevia GK, Bertocchi I, Larkum ME, Sprengel R, Bading H, Charlet A, Grinevich V. (2019) A Fear Memory Engram and Its Plasticity in the Hypothalamic Oxytocin System. Neuron.103:133-146.e8.

Yaeger CE, Ringach DL, Trachtenberg JT. (2019) Neuromodulatory control of localized dendritic spiking in critical period cortex. Nature 567:100-104.

Stephenson-Jones M., Bravo-Rivera C., Ahrens S., Furlan A., Ferndandes-Henriques C., Li B. bioRxiv preprint, posted 3/31/19. https://www.biorxiv.org/content/10.1101/594887v1

Falkner AL, Grosenick L, Davidson TJ, Deisseroth K, Lin D. (2016) Hypothalamic control of male aggression seeking behavior. Nat Neurosci 19:596.

Zhang K., Chen CD, Monosov IE (2019) Novelty, Salience, and Surprise Timing are Signaled by Neurons in the Basal Forebrain. Current Biology 29:134.

Baek J, Lee S, Cho T, Kim SW, Kim M, Yoon Y, Kim KK, Byun J, Kim SJ, Jeong J, Shin HS. (2019) Neural Circuits Underlying a Psycho-therapeutic Regimen for Fear Disorders. Nature, 566: 339.

Pryluk R., Kfir Y., Gelbard-Sagiv H., Fried I., Paz R. (2019) A Tradeoff in the Neural Code Between Regions and Species. Cell 176: 597-609.

Popper, K. (1935) Theory. In The Logic of Scientific Discovery. London and New York: Routledge Classics.

Ronovsky M, Zambon A, Cicvaric A, Boehm V, Hoesel B, Moser BA, Yang J, Schmid JA, Haubensak WE, Monje FJ, Pollak DD. (2019) A role for miR-132 in learned safety. Sci Reports 9: 528.

Seo C, Guru A, Jin M, Ito B, Sleezer BJ, Ho YY, Wang E, Boada C, Krupa NA, Kullakanda DS, Shen CX, Warden MR. (2019) Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode. Science. 363:538-542.

Corder G., Ahanonu B., Grewe B.F., Wang D., Schnitzer M.J., Scherrer G. (2019) An amygdalar neural ensemble that encodes the unpleasantness of pain. Science 363: 276-281.

Zhang X., Li B. (2018) Population coding of valence in basolateral amygdala. Nat Comm 9: 5195.

Nelson A., Mooney R. (2016) The basal forebrain and motor cortex provide convergent yet distinct movement-related inputs to the auditory cortex. Neuron, 90: 635-648.

Allsop SA, Wichmann R, Mills F, Burgos-Robles A, Chang CJ, Felix-Ortiz AC, Vienne A, Beyeler A, Izadmehr EM, Glober G, Cum MI, Stergiadou J, Anandalingam KK, Farris K, Namburi P, Leppla CA, Weddington JC, Nieh EH, Smith AC, Ba D, Brown EN, Tye KM. (2018) Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning. Cell, 10.1016/j.cell.2018.04.004

Ren J, Friedmann D, Xiong J, Liu CD, Ferguson BR, Weerakkody T, DeLoach KE, Ran C, Pun A, Sun Y, Weissbourd B, Neve RL, Huguenard J, Horowitz MA, Luo L. (2018) Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems. Cell, doi: 10.1016/j.cell.2018.07.043

Aitta-Aho T, Hay YA, Phillips BU, Saksida LM, Bussey TJ, Paulsen O, Apergis-Schoute J. (2018) Basal Forebrain and Brainstem Cholinergic Neurons Differentially Impact Amygdala Circuits and Learning-Related Behavior. Curr Biol, doi: 10.1016/j.cub.2018.06.064.

Giardino WJ, Eban-Rothschild A, Christoffel DJ, Li SB, Malenka RC, de Lecea L. (2018) Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states. Nat Neurosci 21:1084-1095.

Ahrens S., Wu M.V., Furlan A., Hwang G-R., Paik R., Li H., Penzo M., Tollukuhn J., Li B. (2018) A central extended amygdala circuit that modulates anxiety. J Neurosci 38: 5567-5583.

Marek R, Xu L, Sullivan RKP, Sah P. (2018) Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction. Nat Neurosci 21:654-658.

Ashley J, Cordy B, Lucia D, Fradkin LG, Budnik V, Thomson T. (2018) Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons. Cell 172: 262-274.

Marek R, Jin J, Goode TD, Giustino TF, Wang Q, Acca GM, Holehonnur R, Ploski JE, Fitzgerald PJ, Lynagh T, Lynch JW, Maren S, Sah P. (2018) Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear. Nat Neuroscie 21:384-392.

Salay N.D.S., Ishiko N., Huberman A.D. (2018) A midline thalamic circuit determines reactions to visual threat. Nature, doi: 10.1038/s41586-018-0078-2.

Kuchibhotla KV, Gill JV, Lindsay GW, Papadoyannis ES, Field RE, Sten TA, Miller KD, Froemke RC (2017) Parallel processing by cortical inhibition enables context-dependent behavior. Nat Neurosci 20: 62-71.

Madarasz TJ, Diaz-Mataix L, Akhand O, Ycu EA, LeDoux JE, Johansen JP. (2016) Evaluation of ambiguous associations in the amygdala by learning the structure of the environment. Nat Neurosci 19: 965

Steinmetz NA, Buetfering C, Lecoq J, Lee CR, Peters AJ, Jacobs EAK, Coen P, Ollerenshaw DR, Valley MT, de Vries SEJ, Garrett M, Zhuang J, Groblewski PA, Manavi S, Miles J, White C, Lee E, Griffin F, Larkin JD, Roll K, Cross S, Nguyen TV, Larsen R, Pendergraft J, Daigle T, Tasic B, Thompson CL, Waters J, Olsen S, Margolis DJ, Zeng H, Hausser M, Carandini M, Harris KD. (2017) Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines. eNeuro. 4(5). pii: ENEURO.0207-17.2017.

Murugan M, Jang HJ, Park M, Miller EM, Cox J, Taliaferro JP, Parker NF, Bhave V, Hur H, Liang Y, Nectow AR, Pillow JW, Witten IB.(2017) Combined social and spatial coding in a descending projection from the prefrontal cortex. Cell 171: 1663 - 1677.

Karl Popper, The Logic of Scientific Discovery, Routledge Press, 1959 (Chapters I and II).

Espinosa N, Alonso A, Morales C, Espinosa P, Chávez AE, Fuentealba P. (2017) Basal Forebrain Gating by Somatostatin Neurons Drives Prefrontal Cortical Activity. doi.org/10.1093/cercor/bhx302

Davis P., Zaki Y., Maguire J., Reijmers LG. (2017) Cellular and oscillatory substrates of fear extinction learning.Nat. Neurosci: doi: 10.1038/nn.4651

Martin-Fernandez M., Jamison S., Robin L.M., Zhao Z., Martin E.D., Aguilar J., Benneyworth M.A., Marsicano G., Araque A. (2017) Synapse-specific astrocyte gating of amygdala-related behavior. Nat Neurosci: doi:10.1038/nn.4649.

Wimmer R.D., Schmitt L.I., Davidson T.J., Nakajima M., Deisseroth K., Halassa M.M. (2015) Thalamic control of sensory selection in divided attention. Nature 526: 705-709.

Han W., Tellez L.A., Rangel Jr. M.J., Motta S.C., Zhang X., Perez I.O., Canteras N.S., Shammah-Lagnado S.J., van den Pol A.N., de Araujo I.E. (2017) Integrated control of predatory hunting by the central nucleus of the amygdala. Cell 168:311-324.

Gielow M.R., Zaborzsky L. (2017) The input-output relationship of the cholinergic basal forebrain. Cell Rep 18:1870-1830.

Halladay L.R., Blair H.T. (2015) Distinct ensembles of medial prefrontal cortex neurons are activated by threatening stimuli that elicit excitation vs. inhibition of movement. J Neurophysiol 114:793-807.

Grewe B.F., Gründemann J., Kitch L.J., Lecoq J.A., Parker J.G., Marshall J.D., Larkin M.C., Jercog P.E., Grenier F., Li J.Z., Lüthi A., Schnitzer M.J. (2017) Neural ensemble dynamics underlying a long-term associative memory. Nature 543: 670-675.

Kim W.B., Cho J-H. (2017) Synaptic targeting of double-projecting ventral CA1 hippocampal neurons to the medial prefrontal cortex and basal amygdala. J Neurosci 37:4868-4882.

Otis J.M., Namboodiri V.M., Matan A.M., Voets E.S., Mohorn E.P., Kosyk O., McHenry J.A., Robinson J.E., Resendez S.L., Rossi M.A., Stuber G.D. (2017) Prefrontal cortex output circuits guide reward seeking through divergent cue encoding. Nature 543: 103-107.

Wallis C.U., Cardinal R.N., Alexander L., Roberts A.C., Clarke H.F. (2017) Opposing roles of primate areas 25 and 32 and their putative rodent homologs in the regulation of negative emotion. PNAS 114: E4075-4084.

Gruene T.M., Lipps J., Rey C.D., Bouck A., Shansky R.M. (2014) Heat exposure in female rats elicits abnormal fear expression and cellular changes in prefrontal cortex and hippocampus. Neurobiol Learn Mem 115: 38-42.

Miniscope workshop (Becky).

Day H.L.L., Reed M.M., Stevenson C.W. (2016) Sex differences in discriminating between cues predicting threat and safety. Neurobiol Learn Mem 133: 196-203.

Danielle and Margo are presenting posters on April 5 & 6 this week at the Undergraduate Research Conference.

A competitive inhibitory circuit for selection of active and passive fear responses.

Fadok JP, Krabbe S, Markovic M, Courtin J, Xu C, Massi L, Botta P, Bylund K, Müller C, Kovacevic A, Tovote P, Lüthi A.(2017) Nature, 542: 196.

An inhibitory pull-push circuit in frontal cortex.

Garcia-Junco-Clemente P., Ikrar T., Tring E., Xu X., Ringach D.L., Trachtenberg J.T. Nat Neurosci 20:389.

Gq/5-HT2c receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice.

Spoida K, Masseck OA, Deneris ES, Herlitze S. PNAS 111:6479.

An intra-amygdala circuit specifically regulates social fear learning

Twinning R.C., Vantrease J.E., Love S., Padival M., Rosenkranz J.A. Nat Neurosci 20: 459. (2017)

Distinct hippocampal pathways mediate dissociable roles of context and memory retrieval.

Xu C., Krabbe S., Grundemann J., Botta P., Fadok J., Osakada F., Saur D., Grewe B.F., Schnitzer M.J., Callaway E.M., Luthi A.

Basal forebrain neuronal inhibition enables rapid behavioral stopping

Jeffrey D. Mayse, Geoffrey M. Nelson, Irene Avila, Michela Gallagher, and Shih-Chieh Lin,

Dysregulation of Prefrontal Cortex-Mediated Slow-Evolving Limbic Dynamics Drives Stress-Induced Emotional Pathology.

Hultman R, Mague SD, Li Q, Katz BM, Michel N, Lin L, Wang J, David LK, Blount C, Chandy R, Carlson D, Ulrich K, Carin L, Dunson D, Kumar S, Deisseroth K, Moore SD, Dzirasa K.

Cortical cholinergic signaling controls the detection of cues

Howard J. Grittona , William M. Howea , Caitlin S. Mallorya , Vaughn L. Hetricka , Joshua D. Berkea , and Martin Sartera,1

A shared neural ensemble links distinct contextual memories encoded close in time

Denise J. Cai1 *, Daniel Aharoni1,2,3*, Tristan Shuman2,3*, Justin Shobe1 *, Jeremy Biane4,5, Weilin Song1 , Brandon Wei1 , Michael Veshkini1 , Mimi La-Vu1 , Jerry Lou2,3, Sergio E. Flores2,3, Isaac Kim1 , Yoshitake Sano1 , Miou Zhou1 , Karsten Baumgaertel6, Ayal Lavi1 , Masakazu Kamata7 , Mark Tuszynski4,5, Mark Mayford6, Peyman Golshani2,3 & Alcino J. Silva1

Emma's Last Day In Lab

July 15, 2025

We bade Emma a bittersweet farewell as she starts her postdoc at Regeneron. It’s been a true pleasure working with Emma and having her as a lab member. We are excited for this next phase of Emma’s career and are also glad that she will remain in the NYC area. Her awesome work will be coming out in a pre-print very soon!

June Happenings - Axe Throwing & Memory Hub

June 26, 2025

Axe throwing came back by popular demand! Team Metabond vs Team Texas Red competed with bullseyes and Polish pierogies to keep team mates strong.

The June Memory Hub meeting was hosted by Nesha Burghardt at Hunter. This is a monthly meeting where NYC neuroscientists who study learning and memory get together at different institutions across the city to discuss topics in the field in a friendly atmosphere that is geared towards bouncing around new ideas and questions among faculty and trainees. If you are interested in joining, please use the QR code. The next meeting will be a two-day conference in September.

Congratulations to Josh on his UGRC poster

June 11, 2025

Josh did a great job showing his work on how neural activity in the basal forebrain changes between early and late fear extinction at the Hunter UGRC.

This is the first work following up on our recent publication demonstrating that infralimbic inputs to the basal forebrain become more active during extinction learning and constrain defensive behavior. Big thanks to Mia for her work with Josh on this project and we have lots more to come!

Congratulations to Nawshin on receiving the CUNY Jonas E. Salk Award

May 31, 2025

Nawshin’s excellent work on the cognitive and cellular effects of acute vs chronic demyelination was recognized with the Jonas E. Salk Award! Thank you to Carmen Melendez-Vasquez, our partner in crime and resident myelin and multiple sclerosis expert, for her insight and co-mentorship. Nawshin’s work delves into how progressive demyelination affects anxiety, memory and neural activity in relevant brain regions.

New Paper Alert 📰📢

May 06, 2025

In our new paper we show the role of the infralimbic-to-ventral pallidum pathway in fear extinction learning and compare it to the more studied infralimbic-amygdala pathway.

We first show that IL projections to the ventral pallidum (VP) are denser than IL projections to the basolateral amygdala (BLA), especially from deeper layers.

We then show that neurons in the IL-ventral pallidum pathway become more active and excitable during extinction learning than retrieval.

We also show that inhibiting this pathway during extinction learning prevents the decrease in defensive freezing behavior (but inhibiting the PL-to-ventral pallidum pathway has no effect on extinction learning).

We propose a model of the IL acting as a switchboard operator when it communicates with downstream structures during fear extinction. During extinction learning, IL output to the ventral pallidum is more active, acting to constrain defensive freezing. Then, during extinction retrieval, IL output to the BLA is more active helping downregulate amygdala output (as shown in other work).

Congratulations to everyone whose work contributed to this finding. It is a bittersweet celebration, because we lost Carolina to health complications in August of 2024. We dedicate this work to her fiery spirit.

Thanks to members of the Friedman Lab for their help with the in-vitro recordings.

Neuroscientists Talk Shop

February 26, 2025

I recently had the pleasure of visiting several universities to talk about our work, and meet with lots of great neuroscientists working on the neuro-glial biology of learning and sensory processing. A big thank you to Anthony Burgos-Robles for hosting me at the University of Texas at San Antonio, Bénédicte Amilhon for hosting me at the Université de Montréal, and Susan Sangha for hosting me at the University of Indiana. Take a look at their work to learn more about learning!

At University of Texas San Antonio, I had the chance to speak with Charlie Wilson on his podcast Neuroscientists Talk Shop, where we discussed all things amygdala with Tony Burgos-Robles and Itamar Lerner

New paper celebration lunch

February 06, 2025

Our new paper in collaboration with the Burghardt Lab, “Social isolation during adolescence differentially affects spatial learning in adult male and female mice” is now out in Learning & Memory.

Champagne alley with Nesha Burghardt, Sadiyah Hanif, Jinah Lee and Mia Sclar

Hanif S, Sclar M, Lee J, Nichols C, Likhtik E, Burghardt NS. Social isolation during adolescence differentially affects spatial learning in adult male and female mice. Learn Mem. 2025 Jan 17;32(1):a054059.

Secret Holiday Lab Mate 2024 Game Night

February 06, 2025

the 2024 Secret Lab Mate board

We even beamed in Katie from Buenos Aires to play Codenames

One of Emma’s lucky code words is "satellite”

Congratulations to Dr. Emma Denholtz on a successful PhD defense!

February 06, 2025

On December 5, Emma defended her thesis, detailing a novel form of learning-dependent plasticity in the prefrontal cortex, which depends on neuro-glial interactions.

Celebrating Emma’s successful defense with a few members of her fantastic thesis committee, Patrizia Casaccia and Carmen Melendez. A heartfelt thanks also goes out to Susan Sangha and Nesha Burghardt for all of their guidance and advice on Emma’s work.

Emma giving a public seminar to a packed seminar room.

Emma’s Defense Avatar, She-RA, Princess of Power!

SFN 2024 in Chicago 10/5 - 10/9

October 04, 2024

Members of the lab are showing some fantastic work in Chicago this year

A season for congratulations and events!

May 24, 2024

Congratulations to Yuval who is leaving after more than 3 years in the lab to start an MD-PhD program at NYU!!

Congratulations to Nawshin who is graduating as a Valedictorian from Macaulay Honors!!

Congratulations to Mia who ran her first half-marathon, covering 13.1 miles of Brooklyn!!

Undergraduates Rock Spring Conferences - Congratulations Nawshin!

May 03, 2024

The undergrads have been doing a stellar job showcasing their work at spring conferences this year. Nawshin took home several awards for her work on the differential effects of acute vs chronic demyelination on behavior, myelin content and neural activity across the brain. Congratulations Nawshin!

Nawshin won a Best Poster award at Hunter’s UGRC.

Nawshin also won the Livingston Welch Award for Research from the Hunter Psychology Dept.

At the Hunter UGRC, George showed how chronic stress results in increased anxiety-like behavior even during a prolonged exposure to a non-stressful environment.

Congratulations to Dr. Carolina M. Fernandes-Henriques!!

March 14, 2024

On January 16th, Carolina beautifully defended her thesis, “The Role of the Infralimbic-Basal Forebrain Pathway in Fear Extinction”. It was a wonderful event and the first manuscript from her work is on its way out.

A heartfelt thank you to Carolina’s fantastic committee: Rob Froemke, Allyson Friedman, Andy Delamater, and Susana Mingote. Their contributions and discussions were most welcome and appreciated.

As Carolina is getting a PhD, she showed us her matrilineal lineage in Portugal. Each succeeding generation achieves a more advanced degree.

Lots of love came in from the room and via Zoom from Portugal.

Dr. Henriques’s celebratory cake and cheese bounty

Congratulations to Rhonda and Emma!

December 06, 2023

Congratulations to Rhonda (seen here as Green Fluorescent Protein) on passing her qualifying exam and moving on to candidacy!

Congratulations to Emma (seen here as Dylight 405) for getting accepted to the Advanced Neuroimaging Techniques course at Max Planck and for winning a Travel Award!

The Fluorescent Proteins at the Biology Halloween party

SFN 2023

December 06, 2023

We had a great time catching up with all the people, the science, and the tech at SfN in DC.

Breakfast Club style at SfN in DC (missing Nawshin, George, and Katie)

Carolina showing her thesis work on circuit communication during extinction learning

Emma showing her thesis work on oligodendrocyte - neuron interactions in learning

The mysteries of the Olive Garden were sampled en route back to NYC

Catch up with us at SFN

November 11, 2023

We will be at SFN, presenting our work and that of others.

Webinar on Making Posters for SFN

November 01, 2023

If you’re new to making posters, take a look at our SFN Webinar on “How To Make and Present a Poster”. In it, Marina Picciotto, Steve Maren, and I discuss various aspects of making a poster (from visuals to content), how to present to different audiences, and how to organize post-presentation networking.

https://neuronline.sfn.org/professional-development/how-to-make-and-present-a-poster-for-neuroscience-2023

Also, take a look at the webinar “Maximizing Your Time at SFN’s Annual Meeting” with Janice Naegele and Veronica Galvin, for strategies on how to prevent feeling overwhelmed.

Why am I scared of bridges?

October 06, 2023

BBC Crowd Science (produced by Hannah Fisher, hosted by Caroline Steel) covered phobias in an episode titled “Why am I scared of bridges?”, where we discussed the circuitry of fear, and Caroline covers lots of other aspects of phobias, such as cultural influences and therapeutic approaches. Caroline even gets therapy for her phobia of elevators. Take a listen.

Pavlovian 2023 in Austin TX

September 28, 2023

We had a wonderful time presenting our work and learning from others at the Pavlovian conference in Austin. Lots of interesting talks, posters, and people.

Carolina and Emma showing their projects

Emma’s confocal images of PV cells are great for staging a talk that showcases the role of prefrontal interneurons

Jinah and Mia went full TX with the bolo ties

IBRO 2023

September 14, 2023

The IBRO conference in Granada was lots of fun with 5 days of great science in a beautiful city. Sara Mederos (Wellcome Center, UCL) and Mario Martin-Fernandez (University of Bordeaux) organized a wonderful symposium, “From Negative Emotion to Defensive Behaviors”, where Sara, Mario, Rony Paz (Weizmann Institute), and I shared new data on circuits of emotion regulation. Olé!