Paper We're Discussing This Week:

Hasan MT, Althammer F, Silva da Gouveia M, Goyon S, Eliava M, Lefevre A, Kerspern D, Schimmer J, Raftogianni A, Wahis J, Knobloch-Bollmann HS, Tang Y, Liu X, Jain A, Chavant V, Goumon Y, Weislogel JM, Hurlemann R, Herpertz SC, Pitzer C, Darbon P, Dogbevia GK, Bertocchi I, Larkum ME, Sprengel R, Bading H, Charlet A, Grinevich V. (2019) A Fear Memory Engram and Its Plasticity in the Hypothalamic Oxytocin System. Neuron.103:133-146.e8.

Previously:

Yaeger CE, Ringach DL, Trachtenberg JT. (2019) Neuromodulatory control of localized dendritic spiking in critical period cortex. Nature 567:100-104.

Stephenson-Jones M., Bravo-Rivera C., Ahrens S., Furlan A., Ferndandes-Henriques C., Li B. bioRxiv preprint, posted 3/31/19. https://www.biorxiv.org/content/10.1101/594887v1

Falkner AL, Grosenick L, Davidson TJ, Deisseroth K, Lin D. (2016) Hypothalamic control of male aggression seeking behavior. Nat Neurosci 19:596.

Zhang K., Chen CD, Monosov IE (2019) Novelty, Salience, and Surprise Timing are Signaled by Neurons in the Basal Forebrain. Current Biology 29:134.

Baek J, Lee S, Cho T, Kim SW, Kim M, Yoon Y, Kim KK, Byun J, Kim SJ, Jeong J, Shin HS. (2019) Neural Circuits Underlying a Psycho-therapeutic Regimen for Fear Disorders. Nature, 566: 339.

Pryluk R., Kfir Y., Gelbard-Sagiv H., Fried I., Paz R. (2019) A Tradeoff in the Neural Code Between Regions and Species. Cell 176: 597-609.

Popper, K. (1935) Theory. In The Logic of Scientific Discovery. London and New York: Routledge Classics.

Ronovsky M, Zambon A, Cicvaric A, Boehm V, Hoesel B, Moser BA, Yang J, Schmid JA, Haubensak WE, Monje FJ, Pollak DD. (2019) A role for miR-132 in learned safety. Sci Reports 9: 528.

Seo C, Guru A, Jin M, Ito B, Sleezer BJ, Ho YY, Wang E, Boada C, Krupa NA, Kullakanda DS, Shen CX, Warden MR. (2019) Intense threat switches dorsal raphe serotonin neurons to a paradoxical operational mode. Science. 363:538-542.

Corder G., Ahanonu B., Grewe B.F., Wang D., Schnitzer M.J., Scherrer G. (2019) An amygdalar neural ensemble that encodes the unpleasantness of pain. Science 363: 276-281.

Zhang X., Li B. (2018) Population coding of valence in basolateral amygdala. Nat Comm 9: 5195.

Nelson A., Mooney R. (2016) The basal forebrain and motor cortex provide convergent yet distinct movement-related inputs to the auditory cortex. Neuron, 90: 635-648.

Allsop SA, Wichmann R, Mills F, Burgos-Robles A, Chang CJ, Felix-Ortiz AC, Vienne A, Beyeler A, Izadmehr EM, Glober G, Cum MI, Stergiadou J, Anandalingam KK, Farris K, Namburi P, Leppla CA, Weddington JC, Nieh EH, Smith AC, Ba D, Brown EN, Tye KM. (2018) Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning. Cell, 10.1016/j.cell.2018.04.004

Ren J, Friedmann D, Xiong J, Liu CD, Ferguson BR, Weerakkody T, DeLoach KE, Ran C, Pun A, Sun Y, Weissbourd B, Neve RL, Huguenard J, Horowitz MA, Luo L. (2018) Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems. Cell, doi: 10.1016/j.cell.2018.07.043

Aitta-Aho T, Hay YA, Phillips BU, Saksida LM, Bussey TJ, Paulsen O, Apergis-Schoute J. (2018) Basal Forebrain and Brainstem Cholinergic Neurons Differentially Impact Amygdala Circuits and Learning-Related Behavior. Curr Biol, doi: 10.1016/j.cub.2018.06.064.

Giardino WJ, Eban-Rothschild A, Christoffel DJ, Li SB, Malenka RC, de Lecea L. (2018) Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states. Nat Neurosci 21:1084-1095.

Ahrens S., Wu M.V., Furlan A., Hwang G-R., Paik R., Li H., Penzo M., Tollukuhn J., Li B. (2018) A central extended amygdala circuit that modulates anxiety. J Neurosci 38: 5567-5583.

Marek R, Xu L, Sullivan RKP, Sah P. (2018) Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction. Nat Neurosci 21:654-658.

Ashley J, Cordy B, Lucia D, Fradkin LG, Budnik V, Thomson T. (2018) Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons. Cell 172: 262-274.

Marek R, Jin J, Goode TD, Giustino TF, Wang Q, Acca GM, Holehonnur R, Ploski JE, Fitzgerald PJ, Lynagh T, Lynch JW, Maren S, Sah P. (2018) Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear. Nat Neuroscie 21:384-392.

Salay N.D.S., Ishiko N., Huberman A.D. (2018) A midline thalamic circuit determines reactions to visual threat. Nature, doi: 10.1038/s41586-018-0078-2.

Kuchibhotla KV, Gill JV, Lindsay GW, Papadoyannis ES, Field RE, Sten TA, Miller KD, Froemke RC (2017) Parallel processing by cortical inhibition enables context-dependent behavior. Nat Neurosci 20: 62-71.

Madarasz TJ, Diaz-Mataix L, Akhand O, Ycu EA, LeDoux JE, Johansen JP. (2016) Evaluation of ambiguous associations in the amygdala by learning the structure of the environment. Nat Neurosci 19: 965

Steinmetz NA, Buetfering C, Lecoq J, Lee CR, Peters AJ, Jacobs EAK, Coen P, Ollerenshaw DR, Valley MT, de Vries SEJ, Garrett M, Zhuang J, Groblewski PA, Manavi S, Miles J, White C, Lee E, Griffin F, Larkin JD, Roll K, Cross S, Nguyen TV, Larsen R, Pendergraft J, Daigle T, Tasic B, Thompson CL, Waters J, Olsen S, Margolis DJ, Zeng H, Hausser M, Carandini M, Harris KD. (2017) Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines. eNeuro. 4(5). pii: ENEURO.0207-17.2017.

Murugan M, Jang HJ, Park M, Miller EM, Cox J, Taliaferro JP, Parker NF, Bhave V, Hur H, Liang Y, Nectow AR, Pillow JW, Witten IB.(2017) Combined social and spatial coding in a descending projection from the prefrontal cortex. Cell 171: 1663 - 1677.

Karl Popper, The Logic of Scientific Discovery, Routledge Press, 1959 (Chapters I and II).

Espinosa N, Alonso A, Morales C, Espinosa P, Chávez AE, Fuentealba P. (2017) Basal Forebrain Gating by Somatostatin Neurons Drives Prefrontal Cortical Activity. doi.org/10.1093/cercor/bhx302

Davis P., Zaki Y., Maguire J., Reijmers LG. (2017) Cellular and oscillatory substrates of fear extinction learning.Nat. Neurosci: doi: 10.1038/nn.4651

Martin-Fernandez M., Jamison S., Robin L.M., Zhao Z., Martin E.D., Aguilar J., Benneyworth M.A., Marsicano G., Araque A. (2017) Synapse-specific astrocyte gating of amygdala-related behavior. Nat Neurosci: doi:10.1038/nn.4649.

Wimmer R.D., Schmitt L.I., Davidson T.J., Nakajima M., Deisseroth K., Halassa M.M. (2015) Thalamic control of sensory selection in divided attention. Nature 526: 705-709.

Han W., Tellez L.A., Rangel Jr. M.J., Motta S.C., Zhang X., Perez I.O., Canteras N.S., Shammah-Lagnado S.J., van den Pol A.N., de Araujo I.E. (2017) Integrated control of predatory hunting by the central nucleus of the amygdala. Cell 168:311-324.

Gielow M.R., Zaborzsky L. (2017) The input-output relationship of the cholinergic basal forebrain. Cell Rep 18:1870-1830.

Halladay L.R., Blair H.T. (2015) Distinct ensembles of medial prefrontal cortex neurons are activated by threatening stimuli that elicit excitation vs. inhibition of movement. J Neurophysiol 114:793-807.

Grewe B.F., Gründemann J., Kitch L.J., Lecoq J.A., Parker J.G., Marshall J.D., Larkin M.C., Jercog P.E., Grenier F., Li J.Z., Lüthi A., Schnitzer M.J. (2017) Neural ensemble dynamics underlying a long-term associative memory. Nature 543: 670-675.

Kim W.B., Cho J-H. (2017) Synaptic targeting of double-projecting ventral CA1 hippocampal neurons to the medial prefrontal cortex and basal amygdala. J Neurosci 37:4868-4882.

Otis J.M., Namboodiri V.M., Matan A.M., Voets E.S., Mohorn E.P., Kosyk O., McHenry J.A., Robinson J.E., Resendez S.L., Rossi M.A., Stuber G.D. (2017) Prefrontal cortex output circuits guide reward seeking through divergent cue encoding. Nature 543: 103-107.

Wallis C.U., Cardinal R.N., Alexander L., Roberts A.C., Clarke H.F. (2017) Opposing roles of primate areas 25 and 32 and their putative rodent homologs in the regulation of negative emotion. PNAS 114: E4075-4084.

Gruene T.M., Lipps J., Rey C.D., Bouck A., Shansky R.M. (2014) Heat exposure in female rats elicits abnormal fear expression and cellular changes in prefrontal cortex and hippocampus. Neurobiol Learn Mem 115: 38-42.

Miniscope workshop (Becky).

Day H.L.L., Reed M.M., Stevenson C.W. (2016) Sex differences in discriminating between cues predicting threat and safety. Neurobiol Learn Mem 133: 196-203.

Danielle and Margo are presenting posters on April 5 & 6 this week at the Undergraduate Research Conference.

A competitive inhibitory circuit for selection of active and passive fear responses.

Fadok JP, Krabbe S, Markovic M, Courtin J, Xu C, Massi L, Botta P, Bylund K, Müller C, Kovacevic A, Tovote P, Lüthi A.(2017) Nature, 542: 196.

An inhibitory pull-push circuit in frontal cortex.

Garcia-Junco-Clemente P., Ikrar T., Tring E., Xu X., Ringach D.L., Trachtenberg J.T. Nat Neurosci 20:389.

Gq/5-HT2c receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice.

Spoida K, Masseck OA, Deneris ES, Herlitze S. PNAS 111:6479.

An intra-amygdala circuit specifically regulates social fear learning

Twinning R.C., Vantrease J.E., Love S., Padival M., Rosenkranz J.A. Nat Neurosci 20: 459. (2017)

Distinct hippocampal pathways mediate dissociable roles of context and memory retrieval.

Xu C., Krabbe S., Grundemann J., Botta P., Fadok J., Osakada F., Saur D., Grewe B.F., Schnitzer M.J., Callaway E.M., Luthi A.

Basal forebrain neuronal inhibition enables rapid behavioral stopping

Jeffrey D. Mayse, Geoffrey M. Nelson, Irene Avila, Michela Gallagher, and Shih-Chieh Lin,

Dysregulation of Prefrontal Cortex-Mediated Slow-Evolving Limbic Dynamics Drives Stress-Induced Emotional Pathology.

Hultman R, Mague SD, Li Q, Katz BM, Michel N, Lin L, Wang J, David LK, Blount C, Chandy R, Carlson D, Ulrich K, Carin L, Dunson D, Kumar S, Deisseroth K, Moore SD, Dzirasa K.

Cortical cholinergic signaling controls the detection of cues

Howard J. Grittona , William M. Howea , Caitlin S. Mallorya , Vaughn L. Hetricka , Joshua D. Berkea , and Martin Sartera,1

A shared neural ensemble links distinct contextual memories encoded close in time

Denise J. Cai1 *, Daniel Aharoni1,2,3*, Tristan Shuman2,3*, Justin Shobe1 *, Jeremy Biane4,5, Weilin Song1 , Brandon Wei1 , Michael Veshkini1 , Mimi La-Vu1 , Jerry Lou2,3, Sergio E. Flores2,3, Isaac Kim1 , Yoshitake Sano1 , Miou Zhou1 , Karsten Baumgaertel6, Ayal Lavi1 , Masakazu Kamata7 , Mark Tuszynski4,5, Mark Mayford6, Peyman Golshani2,3 & Alcino J. Silva1

Orie Shafer at the Neuroscience Colloquium Friday, January 25, 10-11:30 am

January 25, 2019