Paper We're Discussing This Week:

Gu X., Johansen J.P. (2024) Prefrontal encoding of an internal model for emotional inference. BioRxiv: https://doi.org/10.1101/2024.04.22.590529

Previously:

Li HQ, Jiang W, Ling L, Pratelli M, Chen C, Gupta V, Godavarthi SK, Spitzer NC. (2024) Generalized fear after acute stress is caused by change in neuronal cotransmitter identity. Science. 383:1252-1259. doi: 10.1126/science.adj5996.

Zhang X, Liu Y, Hong X, Li X, Meshul CK, Moore C, Yang Y, Han Y, Li WG, Qi X, Lou H, Duan S, Xu TL, Tong X. (2021) NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety. Nat Commun. 12(1):5740. doi: 10.1038/s41467-021-25956-y.

Zhu F, Elnozahy S, Lawlor J, Kuchibhotla KV. The cholinergic basal forebrain provides a parallel channel for state-dependent sensory signaling to auditory cortex. (2023) Nat Neurosci. 26:810-819. doi: 10.1038/s41593-023-01289-5.

Yamada J, Maeda S, Tojo M, Hayashida M, Iinuma KM, Jinno S. (2023) Altered regulation of oligodendrocytes associated with parvalbumin neurons in the ventral hippocampus underlies fear generalization in male mice. Neuropsychopharm. 48:1668-1679. doi: 10.1038/s41386-023-01611-6.

Sun W, Liu Z, Jiang X, Chen MB, Dong H, Liu J, Südhof TC, Quake SR. (2024) Spatial transcriptomics reveal neuron-astrocyte synergy in long-term memory. Nature. Mar;627(8003):374-381. https://www.nature.com/articles/s41586-023-07011-6

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Companion discussion paper:

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Danielle and Margo are presenting posters on April 5 & 6 this week at the Undergraduate Research Conference.

A competitive inhibitory circuit for selection of active and passive fear responses.

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Jeffrey D. Mayse, Geoffrey M. Nelson, Irene Avila, Michela Gallagher, and Shih-Chieh Lin,

Dysregulation of Prefrontal Cortex-Mediated Slow-Evolving Limbic Dynamics Drives Stress-Induced Emotional Pathology.

Hultman R, Mague SD, Li Q, Katz BM, Michel N, Lin L, Wang J, David LK, Blount C, Chandy R, Carlson D, Ulrich K, Carin L, Dunson D, Kumar S, Deisseroth K, Moore SD, Dzirasa K.

Cortical cholinergic signaling controls the detection of cues

Howard J. Grittona , William M. Howea , Caitlin S. Mallorya , Vaughn L. Hetricka , Joshua D. Berkea , and Martin Sartera,1

A shared neural ensemble links distinct contextual memories encoded close in time

Denise J. Cai1 *, Daniel Aharoni1,2,3*, Tristan Shuman2,3*, Justin Shobe1 *, Jeremy Biane4,5, Weilin Song1 , Brandon Wei1 , Michael Veshkini1 , Mimi La-Vu1 , Jerry Lou2,3, Sergio E. Flores2,3, Isaac Kim1 , Yoshitake Sano1 , Miou Zhou1 , Karsten Baumgaertel6, Ayal Lavi1 , Masakazu Kamata7 , Mark Tuszynski4,5, Mark Mayford6, Peyman Golshani2,3 & Alcino J. Silva1

Congratulations to Jenny on winning the Jonas E. Salk Scholarship!

June 08, 2020

Jenny will be heading off to University of Rochester Medical School with a Jonas E. Salk Scholarship for her excellent work in the lab on how safety learning positively impacts other behaviors, and the brain. This work has clinical applications and we look forward to checking in on her progress as she learns about other ways to keep everyone healthy.