Paper We're Discussing This Week:

Gu X., Johansen J.P. (2024) Prefrontal encoding of an internal model for emotional inference. BioRxiv: https://doi.org/10.1101/2024.04.22.590529

Previously:

Li HQ, Jiang W, Ling L, Pratelli M, Chen C, Gupta V, Godavarthi SK, Spitzer NC. (2024) Generalized fear after acute stress is caused by change in neuronal cotransmitter identity. Science. 383:1252-1259. doi: 10.1126/science.adj5996.

Zhang X, Liu Y, Hong X, Li X, Meshul CK, Moore C, Yang Y, Han Y, Li WG, Qi X, Lou H, Duan S, Xu TL, Tong X. (2021) NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety. Nat Commun. 12(1):5740. doi: 10.1038/s41467-021-25956-y.

Zhu F, Elnozahy S, Lawlor J, Kuchibhotla KV. The cholinergic basal forebrain provides a parallel channel for state-dependent sensory signaling to auditory cortex. (2023) Nat Neurosci. 26:810-819. doi: 10.1038/s41593-023-01289-5.

Yamada J, Maeda S, Tojo M, Hayashida M, Iinuma KM, Jinno S. (2023) Altered regulation of oligodendrocytes associated with parvalbumin neurons in the ventral hippocampus underlies fear generalization in male mice. Neuropsychopharm. 48:1668-1679. doi: 10.1038/s41386-023-01611-6.

Sun W, Liu Z, Jiang X, Chen MB, Dong H, Liu J, Südhof TC, Quake SR. (2024) Spatial transcriptomics reveal neuron-astrocyte synergy in long-term memory. Nature. Mar;627(8003):374-381. https://www.nature.com/articles/s41586-023-07011-6

Walker EY, Pohl S, Denison RN, Barack DL, Lee J, Block N, Ma WJ, Meyniel F. (2023) Studying the neural representations of uncertainty. Nature Neuroscience, 10.1038/s41593-023-01444-y

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Companion discussion paper:

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Danielle and Margo are presenting posters on April 5 & 6 this week at the Undergraduate Research Conference.

A competitive inhibitory circuit for selection of active and passive fear responses.

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Distinct hippocampal pathways mediate dissociable roles of context and memory retrieval.

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Basal forebrain neuronal inhibition enables rapid behavioral stopping

Jeffrey D. Mayse, Geoffrey M. Nelson, Irene Avila, Michela Gallagher, and Shih-Chieh Lin,

Dysregulation of Prefrontal Cortex-Mediated Slow-Evolving Limbic Dynamics Drives Stress-Induced Emotional Pathology.

Hultman R, Mague SD, Li Q, Katz BM, Michel N, Lin L, Wang J, David LK, Blount C, Chandy R, Carlson D, Ulrich K, Carin L, Dunson D, Kumar S, Deisseroth K, Moore SD, Dzirasa K.

Cortical cholinergic signaling controls the detection of cues

Howard J. Grittona , William M. Howea , Caitlin S. Mallorya , Vaughn L. Hetricka , Joshua D. Berkea , and Martin Sartera,1

A shared neural ensemble links distinct contextual memories encoded close in time

Denise J. Cai1 *, Daniel Aharoni1,2,3*, Tristan Shuman2,3*, Justin Shobe1 *, Jeremy Biane4,5, Weilin Song1 , Brandon Wei1 , Michael Veshkini1 , Mimi La-Vu1 , Jerry Lou2,3, Sergio E. Flores2,3, Isaac Kim1 , Yoshitake Sano1 , Miou Zhou1 , Karsten Baumgaertel6, Ayal Lavi1 , Masakazu Kamata7 , Mark Tuszynski4,5, Mark Mayford6, Peyman Golshani2,3 & Alcino J. Silva1

July 13th - FENS virtual seminar session (13:00 - 14:30 British Summer Time!)

July 13, 2020

If you are attending FENS, virtually stop in to say hello at our session, where we on focus on how to develop new therapeutic approaches to battle fearful and addictive memories.

S32 - The eternal sunshine of the spotless mind: recent advances to reduce fear and addictive memories

Bianca Silva (Ecole Polytechnique Fédérale de Lausanne): A thalamo-amygdalar circuit underlying the extinction of remote fear memories

Kerry Ressler (Harvard Medical School): Biomarkers of Trauma Response and Recovery: Intermediate Phenotypes as Targets for Interfering with Trauma Memories?

Ekaterina Likhtik (Hunter College, CUNY): Safety training as a therapeutic tool to improve fear discrimination: translational implications.

Amy Milton (University of Cambridge): Preventing Drug Relapse by Modifying Memories: Challenges and Opportunities in Exploiting Reconsolidation to Treat Addiction.